Surfactants should be studied before being used in practice when selecting varieties

2023-02-08 15:18:38

The application of surfactants in aquatic pharmaceutical preparations can improve the appearance properties of the production process and the form of administration, such as stability, clarity, hardness, water solubility, disintegration, solubility, color and taste, etc. In actual application, it can improve the bioavailability of pharmaceutical preparations, but on the other hand, improper use of surfactants will interact with the ingredients in the drug prescription and cause physical and chemical changes (redox, catalytic hydrolysis), which will affect the pharmaceutical preparations The stability of the product, and even affect the curative effect, should be studied before being used in practice when selecting varieties.

Along with the unique activities of aquatic animals, the way of drug administration is also very different from that of terrestrial animals. The administration methods for aquatic animals are generally water administration and feed mixing. However, since the latter administration is generally through the water body, there are limitations on dissolution loss, feed disintegration time and palatability. So far, the way of feed mixing medicine is not very successful, the actual situation is still the main way of drug delivery.

The biggest obstacle to water administration is that many drugs are water-insoluble substances, which need to be transformed into dosage forms to change their physical properties. Surfactants have obvious advantages in providing water-soluble properties of drugs. By selecting appropriate surfactants, many water-insoluble drugs have been successfully applied locally in the field of aquatic products, such as: water-soluble erythromycin, water-soluble chloramphenicol, water-soluble Sexual sulfonamide, water-soluble TMP, etc.

The surfactants that are widely used in this respect are: BS-12, Teg-103, Teg51, sodium lauryl sulfate, Tween, polyvinylpyrrolidone, alcohol ether phosphate, Pingpingjia 0-20, amide ether phosphoric acid Esters, alcohol ether carboxylates, amine oxides, and more and more unique surfactants are used to improve drug solubility.

Due to the huge drug delivery system in aquaculture, the amount of drug use is also increasing. Therefore, the need to improve drug efficacy, reduce drug costs, and reduce the burden on aquaculture is becoming more and more urgent. It is the common wish of the entire aquaculture industry to require high-efficiency and low-cost aquatic drugs. Therefore, the drug properties Research on synergies is increasingly active.