What are the precautions for the use of surfactants?

2021-08-13 16:00:14

Anionic surfactants such as alkyl naphthalene sulfonate, lignin sulfonate, alkyl thiosuccinate, polyoxyvinyl alkyl aryl sulfonate, etc; Nonionic surfactants such as polyoxyvinyl alkyl ether, polyoxyvinyl alkyl phenyl ether, polyoxyvinyl styryl phenyl ether, polyoxyvinyl alkyl ester, low substituted hydroxypropyl cellulose, hydroxymethyl starch sodium, microcrystalline cellulose, cross-linked polyvinylpyrrolidone, cross-linked carboxymethyl fiber sodium, effervescent disintegrating agent, etc, Single or two or more surfactants can be mixed.

The actual production of crystal seeds, such as 20% bensulfuron methyl effervescent tablets, 20% pyrazosulfuron methyl effervescent tablets, 5% imidacloprid effervescent tablets, 18% dichloroquinic acid. Bensulfuron methyl effervescent tablets, 25% bensulfuron methyl effervescent tablets, 25% bensulfuron methyl effervescent tablets, etc.

Disintegrating agent shall be added to the preparation of effervescent tablets (or granules) to speed up the disintegration and make the disintegration time meet the requirements. Due to the different physical and chemical properties of the original drug, there are also great differences in the particle quality, film appearance, moisture absorption and other physical properties formed by the mixture of disintegrating agent and disintegrating agent. In order to achieve a good prescription combination, the disintegration time, suspension or uniformity, dissolution and other indicators are often used to screen the type, optimal ratio or dosage of disintegrating agent and the prepared preparation by orthogonal and uniform design methods, Its effervescence, disintegration, diffusion and stability during storage meet the requirements.

It is an efficient rapid disintegrating agent with good water absorption and expansibility. After full expansion, the volume can be increased by 200 ~ 300 times, and does not form viscous solution in water to hinder the continued disintegration of tablets.

For example, microcrystalline cellulose, as a tablet filler, has three agents of dilution bonding disintegration. It is a multifunctional auxiliary material, which is not only conducive to tablet pressing, but also has a certain disintegration. Due to its water absorption, even a slight excess of wetting agent will not affect the mixing and screening of wet materials, and more uniform particles can be prepared without agglomeration, In wet granulation, the fluidity and compressibility of particles can be significantly improved. It is proved that the same effect can be obtained by powdered cellulose vttacelm80 and vttacel.p290.